Efficacy of repeated doses of diminazene aceturate (Dinazene®) in the treatment of experimental Trypanosoma brucei infection of Albino rats

نویسندگان

  • C. F. Obi Ph.D. Student in Veterinary Protozoology, Department of Agricultural Education, Federal College of Education (Technical) Umunze, Anambra State, Nigeria
  • C. N. Iheagwam Ph.D. Student in Veterinary Entomology, Department of Veterinary Parasitology and Entomology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria
  • D. N. Onah Department of Veterinary Parasitology and Entomology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria
  • E. N. Ugwu Graduated from Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria
  • I. O. Ezeh Ph.D. Student in Veterinary Protozoology, Department of Veterinary Parasitology and Entomology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria
  • O. V. Enemuo Department of Veterinary Parasitology and Entomology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria
  • R. C. Ezeokonkwo Department of Veterinary Parasitology and Entomology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria
چکیده مقاله:

The efficacy of repeated doses of Dinazene® in Albino rats experimentally infected with Trypanosoma brucei (Gboko strain) was investigated. A total of 30 adult female Albino rats weighing 130-190 g were used for the study. They were assigned to six groups (groups A-F) of five rats each. Groups A-D were infected intraperitoneally with 1.0 × 106 trypanosomes in 400 μL of PBS diluted blood while groups E (uninfected treated) and F (uninfected untreated) served as controls. The rats in the groups A-D as well as those in group E were treated with 7.0 mg/kg body weight at day 11 post infection. Groups B, C and D however received two, three and four repeated doses of the drug at weekly intervals following initial treatment. There was complete clearance of the parasite within 120 h post treatment. Parasitaemia, packed cell volume (PCV), total red blood cell (RBC) and white blood cell (WBC) counts, haemoglobin concentration (Hb), rectal temperature, and body weight were used to assay the efficacy of treatment. Following treatment and parasite clearance from the blood, there was improvement (P

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Therapeutic Efficacy Of Cotecxin alone and Its Combination with Diminazene aceturate (Berenil) in the Treatment of Experimental Trypanosoma brucei brucei Infection of Rats

The therapeutic efficacy of Cotecxin (Dihydroartemisinin) alone and its combination with diminazene aceturate (Berenil) was studied in rats infected with Federe strain of Trypanosoma brucei brucei. Fifty healthy adult albino rats of both sexes weighing between 100-180g used were divided into five groups (A-E) of 10 rats each. Rats in groups A-D were each infected with T.b. brucei (1x10trypanoso...

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عنوان ژورنال

دوره 17  شماره 2

صفحات  124- 129

تاریخ انتشار 2016-06-19

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